LARG rabbit pAb
ENT-A5341
Description
| REF | ENT-A5341 |
|---|---|
| Category | Antibody Polyclonal |
| Description | LARG rabbit pAb |
| Source | Rabbit |
| Applications | WB;IHC |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ARHGEF12. AA range:449-498 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 173kD |
| Human Gene ID | 23365 |
| Human Swiss Prot Nº | Q9NZN5 |
| Subcellular Location | Cytoplasm . Membrane . Translocated to the membrane upon stimulation. . |
Other Name: ARHGEF12; KIAA0382; LARG; Rho guanine nucleotide exchange factor 12; Leukemia-associated RhoGEF
Background: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014],