DLC-1 rabbit pAb
ENT-A4568
Description
| REF | ENT-A4568 |
|---|---|
| Category | Antibody Polyclonal |
| Description | DLC-1 rabbit pAb |
| Source | Rabbit |
| Applications | IHC;IF;ELISA |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | Immunohistochemistry: 1/100 – 1/300. Immunofluorescence: 1/200 – 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human RHG07. AA range:61-110 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | |
| Human Gene ID | 10395 |
| Human Swiss Prot Nº | Q96QB1 |
| Subcellular Location | Cytoplasm. Cell junction, focal adhesion. Membrane; Peripheral membrane protein. Colocalizes with EF1A1 at actin-rich regions in the cell periphery. |
Other Name: DLC1; ARHGAP7; KIAA1723; STARD12; Rho GTPase-activating protein 7; Deleted in liver cancer 1 protein; DLC-1; HP protein; Rho-type GTPase-activating protein 7; START domain-containing protein 12; StARD12; StAR-related lipid transfer protein
Background: This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010],