XRCC1 rabbit pAb
ENT-A3928
Description
| REF | ENT-A3928 |
|---|---|
| Category | Antibody Polyclonal |
| Description | XRCC1 rabbit pAb |
| Source | Rabbit |
| Applications | WB;IHC;IF;ELISA |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | Western Blot: 1/500 – 1/2000. Immunohistochemistry: 1/100 – 1/300. ELISA: 1/10000. Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human XRCC1. AA range:517-566 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 70kD |
| Human Gene ID | 7515 |
| Human Swiss Prot Nº | P18887 |
| Subcellular Location | Nucleus . Moves from the nucleoli to the global nuclear chromatin upon DNA damage. . |
Other Name: XRCC1; DNA repair protein XRCC1; X-ray repair cross-complementing protein 1
Background: The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008],