PUMA rabbit pAb
ENT-A3550
Description
| REF | ENT-A3550 |
|---|---|
| Category | Antibody Polyclonal |
| Description | PUMA rabbit pAb |
| Source | Rabbit |
| Applications | WB IF;ELISA |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000 Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PUMA. AA range:120-169 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 23kD |
| Human Gene ID | 27113 |
| Human Swiss Prot Nº | Q9BXH1 |
| Subcellular Location | Mitochondrion . Localized to the mitochondria in order to induce cytochrome c release. |
Other Name: BBC3; PUMA; Bcl-2-binding component 3; JFY-1; p53 up-regulated modulator of apoptosis
Background: This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011],