MLH1 rabbit pAb
ENT-A3133
Description
| REF | ENT-A3133 |
|---|---|
| Category | Antibody Polyclonal |
| Description | MLH1 rabbit pAb |
| Source | Rabbit |
| Applications | WB;IHC |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | WB 1:500-2000;IHC-p 1:50-300 |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MLH1. AA range:441-490 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 85kD |
| Human Gene ID | 4292 |
| Human Swiss Prot Nº | P40692 |
| Subcellular Location | Nucleus . Chromosome . Recruited to chromatin in a MCM9-dependent manner. . |
Other Name: MLH1; COCA2; DNA mismatch repair protein Mlh1; MutL protein homolog 1
Background: This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.[provided by RefSeq, Nov 2009],