TH (phospho Ser71) rabbit pAb
ENT-A1968
Description
| REF | ENT-A1968 |
|---|---|
| Category | Antibody Polyclonal |
| Description | TH (phospho Ser71) rabbit pAb |
| Source | Rabbit |
| Applications | WB;IHC;IF;ELISA |
| Reactivity | Human;Mouse;Rat |
| Reactivity | Human;Mouse;Rat |
| Dilution | Western Blot: 1/500 – 1/2000. Immunohistochemistry: 1/100 – 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Tyrosine Hydroxylase around the phosphorylation site of Ser40. AA range:41-90 |
| Storage Stability | -20°C/1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band KD | 55kD |
| Human Gene ID | 7054 |
| Human Swiss Prot Nº | P07101 |
| Subcellular Location | Cytoplasm, perinuclear region . Nucleus . Cell projection, axon . Cytoplasm . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle . When phosphorylated at Ser-19 shows a nuclear distribution and when phosphorylated at Ser-31 as well at Ser-40 shows a cytosolic distribution (By similarity). Expressed in dopaminergic axons and axon terminals. . |
Other Name: TH; TYH; Tyrosine 3-monooxygenase; Tyrosine 3-hydroxylase; TH
Background: The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008],