Kininogen 1 Rabbit pAb
ENT-A1385
Description
| REF | ENT-A1385 |
|---|---|
| Category | Antibody Polyclonal |
| Description | Kininogen 1 Rabbit pAb |
| Source | Rabbit |
| Applications | WB, IHC |
| Reactivity | Human, Mouse, Rat |
| Reactivity | Human, Mouse, Rat |
| Dilution | WB 1:1500-1,000 IHC 1:100-200 |
| Immunogen | Recombinant Protein |
| Storage Stability | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1mg/mL |
| Observed Band KD | 45-120kDa |
| Human Gene ID | 3827 |
| Human Swiss Prot Nº | P01042 |
| Subcellular Location | Secreted |
Other Name: BDK, Fitzgerald factor, HMWK, Ile Ser Bradykinin Bradykinin, Kallidin I Lysyl bradykinin, kininogen 1, KNG, KNG1
Background: Kininogens are inhibitors of thiol proteases; HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects. LMW-kininogen inhibits the aggregation of thrombocytes; LMW-kininogen is in contrast to HMW-kininogen not involved in blood clottingUCHL1, UCHL3, UCHL5/UCH37, and BRCA-1-associated protein-1 (BAP1) belong to the UCH family of DUBs, which all posses a conserved catalytic domain (UCH domain) of about 230 amino acids. UCHL1 is abundantly expressed in neuronal tissues and testes.