Calreticulin Rabbit pAb
ENT-A1384
Description
| REF | ENT-A1384 |
|---|---|
| Category | Antibody Polyclonal |
| Description | Calreticulin Rabbit pAb |
| Source | Rabbit |
| Applications | WB |
| Reactivity | Human, Mouse, Rat |
| Reactivity | Human, Mouse, Rat |
| Dilution | WB 1:500-1,000 |
| Immunogen | Recombinant Protein |
| Storage Stability | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1mg/mL |
| Observed Band KD | 55kDa |
| Human Gene ID | 811 |
| Human Swiss Prot Nº | P27797 |
| Subcellular Location | Cytoplasm, Endoplasmic reticulum, Extracellular matrix, Sarcoplasmic reticulum, Secreted |
Other Name: CALR, Calregulin, cC1qR, CRP55, CRT, CRTC, ERp60, grp60, HACBP, RO, SSA
Background: Calcium is a universal signaling molecule involved in many cellular functions such as cell motility, metabolism, protein modification, protein folding, and apoptosis. Calcium is stored in the endoplasmic reticulum (ER), where it is buffered by calcium binding chaperones such as calnexin and calreticulin, and is released via the IP3 Receptor channel . Calreticulin also functions as an ER chaperone that ensures proper folding and quality control of newly synthesized glycoproteins. As such, calreticulin presumably does not alter protein folding but regulates proper timing for efficient folding and subunit assembly. Furthermore, calreticulin retains proteins in non-native conformation within the ER and targets them for degradation .