Bmi-1 (F270)Rabbit pAb
ENT-A1381
Description
| REF | ENT-A1381 |
|---|---|
| Category | Antibody Polyclonal |
| Description | Bmi-1 (F270)Rabbit pAb |
| Source | Rabbit |
| Applications | WB |
| Reactivity | Human |
| Reactivity | Human |
| Dilution | WB 1:1,000-2,000 |
| Immunogen | Recombinant Protein |
| Storage Stability | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1mg/mL |
| Observed Band KD | 37-43kDa |
| Human Gene ID | 100532731 |
| Human Swiss Prot Nº | P35226 |
| Subcellular Location | Cytoplasm, Nucleus |
Other Name: PCGF4, Polycomb complex protein BMI 1, RING finger protein 51, RNF51
Background: Bmi1 is a component of the PRC1 complex, which together with Ring1 strongly enhances the E3 ubiquitin ligase activity of the Ring2 catalytic subunit . Bmi1 plays an important role in the regulation of cell proliferation and senescence through repression of the p16 INK4A and p19 ARF genes and is required for maintenance of adult hematopoietic and neural stem cells .