MEK4 (F194)Rabbit pAb
ENT-A1380
Description
| REF | ENT-A1380 |
|---|---|
| Category | Antibody Polyclonal |
| Description | MEK4 (F194)Rabbit pAb |
| Source | Rabbit |
| Applications | WB |
| Reactivity | Human, Mouse, Rat |
| Reactivity | Human, Mouse, Rat |
| Dilution | WB 1:1,000-2,000 |
| Immunogen | Recombinant Protein |
| Storage Stability | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1mg/mL |
| Observed Band KD | 44kDa |
| Human Gene ID | 6416 |
| Human Swiss Prot Nº | P45985 |
| Subcellular Location | Cytoplasm, Nucleus |
Other Name: JNK activating kinase 1, JNKK, JNKK1, MAP kinase kinase 4, MAP2K4, MAPK/ERK kinase 4, MAPKK 4, MAPKK4, MKK4, PRKMK4, SAPK/ERK kinase 1, SEK1, SERK1
Background: SAPK/Erk kinase (SEK1), also known as MEK4 or MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflammatory cytokines . Activation of SEK1 occurs through MEKK phosphorylation of serine and threonine residues at positions 257 and 261, respectively. Like MEK, SEK is a dual-specificity protein kinase that phosphorylates SAPK/JNK at a conserved T*PY* site in its activation loop . Phosphorylation by Akt at Ser80 inhibits SEK1 and suppresses stress-activated signal transduction .