VEGF Rabbit pAb
ENT-A1343
Description
| REF | ENT-A1343 |
|---|---|
| Category | Antibody Polyclonal |
| Description | VEGF Rabbit pAb |
| Source | Rabbit |
| Applications | IHC |
| Reactivity | Human, Rat, Mouse |
| Reactivity | Human, Rat, Mouse |
| Dilution | IHC 1:200-500 |
| Immunogen | Recombinant Protein |
| Storage Stability | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1mg/mL |
| Observed Band KD | 23,45kDa |
| Human Gene ID | 7422 |
| Human Swiss Prot Nº | P15692 |
| Subcellular Location | Secreted |
Other Name: VEGFA antibody, VPF antibody, VEGF120 antibody, Vascular endothelial growth factor antibody
Background: VEGFA, also named as VEGF or VPF, belongs to the PDGF/VEGF growth factor family. It is a growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. VEGFA induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. It binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Defects in VEGFA are associated with microvascular complications of diabetes type 1 (MVCD1). VEGFA has 17 isoforms with MW from 16 to 45 kDa. Some isoforms have homodimer forms (e.g.; VEGFA189 38kDa or VEFGA110 34kDa). VEGF-A exists in at least seven homodimeric isoforms. The monomers consist of 121, 145, 148, 165, 183, 189, or 206 amino acids (PMID:15602010 ). This antibody can recognize all VEGFA isoforms.