MLKL (8H7) Mouse mAb
ENT-A1605
Description
| Ref | ENT-A1605 |
|---|---|
| Category | Antibody Monoclonal |
| Alternative Name | Mixed lineage kinase domain like protein, FLJ34389 |
| Application | IHC |
| Source | Mouse |
| Reactivity | Human |
| Dilution | IHC 1:100-200 |
| Immunogen | Synthetic Peptide |
| Storage Stability | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Concentration | 1mg/mL |
| Observed Band(KD) | 54kDa |
| Human Gene ID | 197259 |
| Human Swiss Prot No | Q8NB16 |
| Subcellular Location | Cell membrane, Cytoplasm, Membrane |
Background: Mixed lineage kinase domain-like protein (MLKL) is a pseudokinase that was identified as downstream target of RIP3 in the necroptosis pathway. During necroptosis RIP3 is phosphorylated at Ser227, which recruits MLKL and leads to its phosphorylation at Thr357 and Ser358.