ErbB-2/HER-2 Mouse mAb
ENT-A1425
Description
| Ref | ENT-A1425 |
|---|---|
| Category | Antibody Monoclonal |
| Alternative Name | CD340, HER 2/neu, HER2, MLN 19, MLN19, NEU, NGL, p185, p185erbB2, Proto oncogene c ErbB 2, Proto oncogene Neu, TKR1 |
| Application | WB, IHC |
| Source | Mouse |
| Reactivity | Human, Rat, Mouse |
| Dilution | WB 1:2,000-4,000 IHC 1:200 |
| Immunogen | Synthetic Peptide |
| Storage Stability | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Concentration | 1mg/mL |
| Observed Band(KD) | 138kDa |
| Human Gene ID | 2064 |
| Human Swiss Prot No | P04626 |
| Subcellular Location | Cytoplasm. Nucleus and Cell membrane |
Background: ErbB 2 is a receptor tyrosine kinase of the ErbB 2 family. It is closely related instructure to the epidermal growth factor receptor. ErbB 2 oncoprotein is detectable in a proportion of breast and other adenocarconomas, as well as transitional cell carcinomas. In the case of breast cancer, expression determined by immunohistochemistry has been shown to be associated with poor prognosis.