Bcl-2 Mouse mAb
ENT-A1421
Description
| Ref | ENT-A1421 |
|---|---|
| Category | Antibody Monoclonal |
| Alternative Name | B-Cell Leukemia/Lymphoma 2 ;B-Cell CLL/Lymphoma 2 |
| Application | WB, IHC, IF |
| Source | Mouse |
| Reactivity | Human, Rat, Mouse |
| Dilution | WB 1:1,000-2,000 IHC 1:200 IF 1:100-200 |
| Immunogen | Synthetic Peptide |
| Storage Stability | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Concentration | 1mg/mL |
| Observed Band(KD) | 26kDa |
| Human Gene ID | 596 |
| Human Swiss Prot No | P10415 |
| Subcellular Location | Mitochondrion outer membrane,Nucleus membrane,Endoplasmic reticulum membrane |
Background: BCL2 is an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. BCL2 suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. It regulates cell death by controlling the mitochondrial membrane permeability.